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Norco is another combination medication that contains hydrocodone and acetaminophen and is commonly used to treat moderate to severe pain. Like other opioid-based pain relievers, hydrocodone works by affecting opioid receptors in the brain and nervous system, which helps reduce the sensation of pain. Acetaminophen enhances this effect by helping relieve pain and reduce fever. Norco may be prescribed after surgery, injury, or certain medical conditions that cause significant discomfort. The medication is usually taken orally in tablet form and should be used only as directed by a healthcare provider. Because it contains an opioid component, Norco carries a risk of dependence if misused or taken for extended periods. For this reason, doctors generally prescribe the lowest effective dose for the shortest possible duration. Common side effects may include nausea, dizziness, constipation, drowsiness, or headache. Patients should avoid alcohol and other sedative medications unless approved by their healthcare provider.